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Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5
Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li
《医学前沿(英文)》 2019年 第13卷 第6期 页码 705-712 doi: 10.1007/s11684-019-0703-y
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
《医学前沿(英文)》 2022年 第16卷 第3期 页码 442-458 doi: 10.1007/s11684-021-0877-y
关键词: T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination
Regeneration of hair cells in the mammalian vestibular system
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 143-151 doi: 10.1007/s11684-016-0451-1
Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animals to recover from hearing and balance deficits. Such regeneration does not occur efficiently in humans and other mammals. Thus, balance deficits become permanent and is a common sensory disorder all over the world. Since Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells after gentamicin-induced damage in mature mammals, significant efforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hair cell loss. Moreover, recently many strategies have been developed to promote the hair cell regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch and Atoh1. This article provides an overview of the recent advances in hair cell regeneration in mammalian vestibular epithelia. Furthermore, this review highlights the current limitations of hair cell regeneration and provides the possible solutions to regenerate functional hair cells and to partially restore vestibular function.
Parametric equations for notch stress concentration factors of rib–deck welds under bending loading
《结构与土木工程前沿(英文)》 2021年 第15卷 第3期 页码 595-608 doi: 10.1007/s11709-021-0720-1
关键词: notch stress concentration factor rib–deck weld parametric analysis regression analysis parametric equation
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
null
《医学前沿(英文)》 2016年 第10卷 第3期 页码 237-249 doi: 10.1007/s11684-016-0464-9
Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
关键词: inner ear cochlea hair cell regeneration Wnt Notch signaling pathways
Crack propagation with different radius local random damage based on peridynamic theory
《结构与土木工程前沿(英文)》 2021年 第15卷 第5期 页码 1238-1248 doi: 10.1007/s11709-021-0695-y
穆志韬
《中国工程科学》 2002年 第4卷 第3期 页码 68-72
依据海军现役飞机的腐蚀环境特点及结构件腐蚀损伤深度拟合规律,采用应力场强法和局部应力应变法分别对疲劳缺口系数Kf及疲劳寿命计算模型进行了分析,提出了一种腐蚀环境下飞机结构疲劳寿命的评定方法。该方法以室温大气环境下的寿命评定结论为依据,考虑了结构件腐蚀损伤后潮湿空气、盐雾、盐雾+SO2等环境介质对疲劳寿命的影响,并结合国产某型飞机机翼前梁缘条腐蚀损伤部位的疲劳寿命及剩余寿命估算实例进行了分析。
Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth
Guozhen CHEN, Pinkuan LIU, Han DING
《机械工程前沿(英文)》 2020年 第15卷 第1期 页码 55-65 doi: 10.1007/s11465-019-0545-y
关键词: fast-steering mirror structural parameter PI controller bandwidth notch filter
Mohammad SALAVATI, Arvin MOJAHEDIN, Ali Hossein Nezhad SHIRAZI
《结构与土木工程前沿(英文)》 2020年 第14卷 第3期 页码 623-631 doi: 10.1007/s11709-020-0616-5
关键词: hexagonal boron-nitride mechanical properties crack notch point defects molecular dynamics
灰色预测模型GM(1,1)的适用性分析及在火灾风险预测中的应用
陈子锦,王福亮,陆守香
《中国工程科学》 2007年 第9卷 第5期 页码 91-94
通过对灰色预测模型———GM(1,1)的理论分析,证明了该模型的预测值及其变化趋势均具有单调 性,进而提出了GM(1,1)模型的适用性判据,并给出了该判据在火灾风险灰色预测中的应用实例。
《医学前沿(英文)》 页码 805-822 doi: 10.1007/s11684-023-1025-7
关键词: CTLA-4 PD-1 PD-L1 immune checkpoint blockade (ICB) metabolic reprogramming combined tumor therapeutic strategies
王学滨,潘一山,张智慧
《中国工程科学》 2010年 第12卷 第2期 页码 40-46
利用FLAC模拟了不同扩容角时圆形巷道的岩爆过程。为了模拟巷道开挖,利用编写的FISH函数删除巷道内部的单元。岩石服从莫尔库仑剪破坏与拉破坏复合的破坏准则,破坏之后呈现应变软化—理想塑性行为。文章的模拟分为3步:首先,将静水压力施加在模型上,直到达到静力平衡状态;然后,利用编写的FISH函数,开挖巷道;最后,计算重新开始,直到达到静力平衡状态。模拟结果表明,随着扩容角的增加,剪切带变宽,岩爆坑变深,破坏单元数目增多,破坏区变大。当扩容角较低时,高剪切应变集中于“狗耳”形岩爆坑位置,剪切带与巷道周边切线之间的夹角较大;当扩容角较高时,高剪切应变集中于巷道周边的一些位置上,剪切带与巷道周边切线之间的夹角较小。该研究结果与Roscoe,Arthur理论相符。
邓运华
《中国工程科学》 2011年 第13卷 第10期 页码 13-18
联邦无监督表示学习 Research Article
张凤达1,况琨1,陈隆1,游兆阳1,沈弢1,肖俊1,张寅1,吴超2,吴飞1,庄越挺1,李晓林3,4,5
《信息与电子工程前沿(英文)》 2023年 第24卷 第8期 页码 1181-1193 doi: 10.1631/FITEE.2200268
关键词: 联邦学习;无监督学习;表示学习;对比学习
王正新,党耀国,刘思峰
《中国工程科学》 2012年 第14卷 第7期 页码 98-102
针对工程中大量存在的非等间距序列的建模问题,提出了非等间距GM(1, 1)幂模型。以平均相对误差绝对值最小化为目标,以模型参数之间的关系为约束,构建了一个非线性优化模型实现非等间距GM(1, 1)幂模型的参数估计。结果表明,非等间距GM(1, 1)幂模型的形式较为灵活,非等间距GM(1, 1)模型和灰色Verhulst模型均是非等间距GM(1, 1)幂模型的特殊情形,幂指数的优化有利于提高建模精度。最后通过一个工程实例验证了非等间距GM(1, 1)幂模型的有效性与实用性。
标题 作者 时间 类型 操作
Unidirectional and stage-dependent roles of Notch1 in Wnt-responsive Lgr5
Hui Jiang, Shan Zeng, Wenli Ni, Yan Chen, Wenyan Li
期刊论文
Parametric equations for notch stress concentration factors of rib–deck welds under bending loading
期刊论文
Structural parameter design method for a fast-steering mirror based on a closed-loop bandwidth
Guozhen CHEN, Pinkuan LIU, Han DING
期刊论文
Mechanical responses of pristine and defective hexagonal boron-nitride nanosheets: A molecular dynamics investigation
Mohammad SALAVATI, Arvin MOJAHEDIN, Ali Hossein Nezhad SHIRAZI
期刊论文
Metabolic interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms
期刊论文